Nucleosome assembly and epigenetic inheritance
نویسندگان
چکیده
منابع مشابه
Histone variants, nucleosome assembly and epigenetic inheritance.
Template copying is the basis for inheritance and specification of genetic information and for the propagation of DNA methylation. However, no templating machinery has been identified that is capable of propagating histone modifications and conformations. Potential solutions to this enigma come from recent insights into histone variants and the specialized complexes that assemble them into nucl...
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The fidelity of epigenetic inheritance or, the precision by which epigenetic information is passed along, is an essential parameter for measuring the effectiveness of the process. How the precision of the process is achieved or modulated, however, remains largely elusive. We have performed quantitative measurement of epigenetic fidelity, using position effect variegation (PEV) in Schizosaccharo...
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Nucleosome remodelling is an essential principle to assure that the packaging of eukaryotic genomes in chromatin remains flexible and adaptable to regulatory needs. Nucleosome remodelling enzymes spend the energy of ATP to alter histone-DNA interactions, to catalyse nucleosome displacement and reassembly, on histone exchange and on the relocation of histone octamers on DNA. Despite these dynami...
متن کاملMechanisms of epigenetic inheritance.
The mechanisms by which stable gene expression patterns are inherited during cell division are not well understood. Chromatin is subject to a number of covalent modifications and it is generally believed that the transfer of these modifications between cell generations plays a critical role in inheritance, though how this occurs is a matter of debate. In one proposed model, replication of chrom...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2010
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-010-0104-0